The only way to destroy them is using hot steam.

After a short walk you will reach the engine room.

Eliminate the enemies and destroy the plank blocking the valve which lowers the ladder.

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On your way you will also find a can of beer inside the locker.

Inside you will find a small EDF supply crate.

Before you destroy it, shoot the puffballs blocking the vent and waiting to explode you in the face.

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Now unblock the fan and keep the “forwards” button pressed down while going up.

that way you will reach a hidden room.

Collect the items found inside, jump back into the shaft and enter another one at the top.

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At the very top, jump down into the canal.

You will come across a fan with electrodes around it and a fuse.

Shoot the fuse and switch off the vent to move on.

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Inside the heated room with moving gears, you will have to pass through the holes found in them.

Look out now to fall between electrical arches by the end.

Above, you will find yourself beside the pistons.

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Shoot all the fuses in the vents around them to stop the machine.

You will have to move between the pistons to reach the last fuse.

After getting out of it, climb up to the top shelf of the room you’re in.

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At the top, go through the window to the next room.

Approach the elevator, jump inside and press the button.

A swarm of Octababies will enter the room.

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Inside the elevator, approach the button by going along the handrail.

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Duke Nukem Forever