In the first part of the fight Nitrus Brio is throwing green and purple vials.

to make it complete this phase you must hurt the opponent six times.

The second phase of the battle will start.

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The green potions thrown by Nitrus Brio make monsters (blobs) appear on the level.

Don’t try using Spin attack to defend from them.

At first there will be only one blob appearing on the level.

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Then there will be two of them and finally even three.

When you face more than one monster, it is important to jump between one to another.

This will reduce the risk of Crash dying from touching the monster after landing.

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The most troublesome part is when Nitrus Brio has only 1 health point left.

At that point he will throw six vials.

You must be prepared for that.

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It is best to start in the upper left corner (above picture).

Jump on one of them and stay there, waiting for Nitrus to get close.

After a few attempts you should find out the right distance.

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to make it finally win, attack Nitrus three times.

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Crash Bandicoot N. Sane Trilogy