Instead followJacksonto a large ladder.
Use the ladder to get back to the main area ofPoint Lookout[#35].
You may now travel to theCalvert Mansion(either on foot or via your Pip-Boy).
Leave the mansion and proceed towards this new destination.
It can be found easily using your personal map and by starting from the pier.
Once you’re there wait for thescientistto contact you[#36]and listen to his proposal.
You must now make a choice whether you want to helpDesmondorCalvert(thebrain).
You will still be allowed to switch your alignment during the course of the final main quest!
Approach a large trash compactor and press the action key to use it[#37].
You must now choose the first option from the list to get rid of thejamming devicegiven to you byDesmond.
Listen to a new transmission fromCalvertand head on to theCalvert Mansion.
Make a few steps forward and witness a HUGE explosion destroying the house.
Find a single carriage and press the action key to mount ajamming deviceon it[#38].
Additionally you must use a nearby switch to start the wheel.
Turn around quickly and get ready to defend yourself against a large group oftribalssent by thebrainto kill you.
Use your most powerful guns, especially since you’ll be in a corner with no place to go.
Once you’ve won transport yourself toCalvert Mansionand witness a huge explosion.
And don’t worry -Desmondis still alive.
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