This page of the Uncharted 4 guide has a walkthrough for chapter 5 Hector Alcazar.
You will learn how to escape as Sam Drake.
You will learn, e.g.
Always pick the weapon you have an easier time to gather ammo for.
A number of encounters await you in one of the larger rooms of the prison.
Initially you will be on the attacking side - shoot at the enemies from the upper balcony.
After a short while you will be forced to defend yourself.
Use covers and prevent the enemies from flanking your position.
Prison yard
After reaching the courtyard of the prison a new encounter will begin.
You must watch out for the stationary machinegun located on top of one of the towers.
Don’t attempt to aim directly at the tower.
Instead, perform some blind fire and make a run at move from cover to cover.
This is crucial, as the covers you will be hiding behind will crumble from the enemy fire.
Wait for the moment the tower gets destroyed and continue your march.
Don’t stop and climb up on top of the wall with blue pipes.
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