This guide page for Uncharted 4 has a walkthrough for the prologue.

You will learn how to attack the enemies on the boat, and how to avoid hitting the rocks.

You will learn, e.g.

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how to destroy enemy boats, how to shoot the enemies, and how to avoid hitting the rocks.

You start the prologue on board of a boat, accompanied by Sam.

You must use it to escape the pursuit.

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Head towards the large island visible on the horizon.

Ignore the smaller boats attacking the heroes.

The impact will destroy them.

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After a short while a larger vessel will appear in the area.

It will start shooting mines at the Drake’s boat.

Approach the boat that Sam is still standing on and climb up on board.

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You must now protect Sam as he is trying to repair the engine of the boat.

Hide behind cover and shoot at the crew of the large ship that will soon approach your position.

Look for the enemy equipped with a grenade launcher.

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Shooting at and eliminating the enemy grenadier should result in the explosion of the enemy boat.

Few more smaller ships will appear in the area afterwards, but they won’t pose such a threat.

During this section your task is to head towards the island.

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However, you must now watch out for and avoid contact with huge rocks emerging from the water.

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Uncharted 4: A Thief’s End